Searchable abstracts of presentations at key conferences in endocrinology

ea0049gp185 | Pituitary & endocrine Tumours | ECE2017

Localization of benign insulinomas using glucagon-like peptide-1 receptor (GLP1-R) SPECT/CT and PET/CT and MRI in a prospective clinical study

Antwi Kwadwo , Fani Melpomeni , Heye Tobias , Nicolas Guillaume , Merkle Elmar , Reubi Jean Claude , Gloor Beat , Wild Damian , Christ Emanuel

Purpose: We aim at prospectively comparing the detection rate of GLP1-R PET/CT vs GLP1-R SPECT/CT vs standardized contrast enhanced 3T-MRI in patients with suspected insulinoma.Methods: 40 patients with neuroglycopenic symptoms due to endogenous hyperinsulinemic hypoglycemia were enrolled.3T-MRI was performed. Afterwards patients received SPECT/CT after injection of 111In-DOTA-exendin-4 and PET/CT after injection of <sup...

ea0041ep590 | Endocrine tumours and neoplasia | ECE2016

Localization of benign insulinomas using glucagon-like peptide-1 receptor (GLP1-R) SPECT/CT and PET/CT in a prospective clinical study

Antwi Kwadwo , Fani Melpomeni , Heye Tobias , Nicolas Guillaume , Merkle Elmar , Reubi Jean Claude , Gloor Beat , Wild Damian , Christ Emanuel

Purpose: The aim of our study is to compare the detection rate of GLP-1R PET/CT and GLP-1R SPECT/CT in patients with a biochemically proven endogenous hyperinsulinemic hypoglycemia. Preliminary results of an ongoing study are reported.Methods: Thirty-three patients (25 females, 8 males, age range 18–80 years, mean 49 years) with neuroglycopenic symptoms due to endogenous hyperinsulinemic hypoglycemia were enrolled (ClinicalTrials.gov, NCT02127541).<...

ea0063gp1 | Adrenal and Neuroendocrine - Tumour | ECE2019

68Ga-exendin-4 PET/CT detects insulinomas in patients with hypoglycemia in multiple endocrine neoplasia type 1

Antwi Kwadwo , Nicolas Guillaume , Fanis Melpomeni , Heye Tobias , Pattou Francois , Grossman Ashley , Chanson Philippe , Reubi Jean Claude , Perren Aurel , Gloor Beat , Vogt Deborah , Wild Damian , Christ Emanuel

Context: Surgical intervention is advised in patients with multiple endocrine neoplasia type-1 (MEN-1) with non-functioning pancreatic neuroendocrine tumors (PanNET) and a size ≥20 mm. However, functioning PanNET such as patients with endogenous hyperinsulinemic hypoglycemia (EHH) due to (one or multiple) insulinomas should be treated surgically independent of size. Reliable preoperative localization of insulinomas is critical for surgical strategy.<p class="abstext"...

ea0041ep607 | Endocrine tumours and neoplasia | ECE2016

Glucagon-like-1 Receptor imaging specifically localizes insulinomas in patients with Multiple Endocrine Neoplasia Type 1 (MEN-1)

Antwi Kwadwo , Fani Melpomeni , Heye Tobias , Nicolas Guillaume , Merkle Elmar , Pattou Francois , Grossmann Ashley , Chanson Philippe , Reubi Jean Claude , Gloor Beat , Wild Damian , Christ Emanuel

Introduction: Surgery is often the only treatment option that can effectively treat patients with insulinoma in MEN-1. However, the surgical intervention should be limited as surgery can not cure patients with MEN-1. It is, therefore, mandatory to correctly localize insulin secreting tumors from other neuroendocrine tumors.Materials and Methods: In this report we include 6 patients with proven endogenous hyperinsulinemic hypoglycemia and neuroglycopenia ...

ea0037gp.28.02 | Endocrine tumours and neoplasia – NETS | ECE2015

Localisation of insulinoma: comparison of glucagon-like peptide 1 receptor SPECT/CT, PET/CT, and MRI: preliminary results of a prospective clinical study

Antwi Kwadwo , Fani Melpomeni , Heye Tobias , Nicolas Guillaume , Merkle Elmar , Reubi Jean Claude , Gloor Beat , Fischli Stefan , Wild Damian , Christ Emanuel

Purpose: We aim at prospectively comparing the detection rate of glucagon-like peptide 1 receptor (GLP1R) PET/CT vs GLP1R SPECT/CT vs standardised contrast enhanced 3T MRI in patients with endogenous hyperinsulinaemic hypoglycaemia.Methods: 14 patients with neuroglycopenic symptoms due to endogenous hyperinsulinaemic hypoglycaemia were already enrolled (mean age 56 years, ten females and four males). A standardized contrast enhanced 3T MRI was performed....